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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 12, No. 3, 2015, pp. 55-67
Bioline Code: tc15049
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 12, No. 3, 2015, pp. 55-67

 en ANTIMICROBIAL ACTIVITY OF CINNAMALDEHYDE, VANILLIN AND KIGELIA AFRICANA check for this species in other resources FRUIT EXTRACTS AGAINST FISH-ASSOCIATED CHRYSEOBACTERIUM check for this species in other resources AND MYROIDES check for this species in other resources SPP. ISOLATES
Chenia, Hafizah Yousuf

Abstract

Background: Members of the family Flavobacteriaceae exhibit intrinsic multi-drug resistance, which hampers their effective eradication. Phytochemicals are being explored as alternatives to the use of antimicrobial agents in aquaculture since they have growth-promoting, immunestimulating, and antimicrobial properties.
Materials and Methods: The susceptibility of 36 Chryseobacterium check for this species in other resources and seven Myroides check for this species in other resources spp. isolates from salmon, tilapia and trout as well as 19 selected Flavobacteriaceae type strains to cinnamaldehyde, vanillin and four crude Kigelia africana check for this species in other resources extracts (ethyl acetate, dichloromethane, methanol and hexane), was assessed using disc diffusion assays and compared to standard antimicrobial agents, ampicillin and tetracycline using activity indices.
Results: Cinnamaldehyde (≥250 μg/ml) was the most effective (77. 8 – 100% susceptibility) while vanillin was the least effective with inhibitory activity only at 1000 μg/ml. The K. africana hexane extract (4 mg/ml) was the most effective, with only 11.3% of isolates displaying resistance, while 94.4% of isolates demonstrated resistance to ampicillin and 38.9% susceptibility to tetracycline. K. africana extract inhibitory efficacy decreased in the following order: hexane > ethyl acetate > dichloromethane > methanol. Cinnamaldehyde and K. africana EX 4 activity indices ≥ 1 were obtained for 83.3 - 97.2% and 25% of Chryseobacterium spp. isolates, respectively, relative to tetracycline.
Conclusions: Cinnamaldehyde and K. africana fruit hexane extracts are promising candidates to be tested for their efficacy in the treatment of Chryseobacterium/Myroides-associated fish infections. These phytochemicals might serve as environmentally-friendly, cost-effective alternatives to the use of antimicrobial agents in aquaculture farms, with a lesser chance of resistance development.

Keywords
phytotherapy; cinnamaldehyde; vanillin; Kigelia; Chryseobacterium; Myroides

 
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