L. proved to have anti-inflammatory, antihyperglycemic, antioxidant, antiglycation, analgesic and
antipyretic activities. It also has been used in Ayurveda and folk medicine for the treatment of rheumatism, fever and earache.
The present study was aimed to evaluate the effect of Cardiospermum halicabum
leaf extract (CHE) on membrane-bound ATPases
in streptozotocin (STZ)-induced diabetic rats.
Diabetes was induced in male albino Wistar rats by intraperitonial administration of STZ (40 mg/kg BW). CHE (200 mg/kg BW) or
glibenclamide (600 μg/kg BW) was administered orally once daily for 45 days to normal and STZ-induced diabetic rats.
The activities of membrane-bound ATPases such as total ATPase, Na+
-ATPase and Ca2+
-ATPase were significantly
decreased in erythrocytes and tissues of STZ-induced diabetic rats. Oral administration of CHE to diabetic rats significantly increased the
activities of these enzymes towards near normalcy.
Thus, the present study indicates that the beneficial role of membrane-bound ATPases in STZ-induced diabetic rats. The
antihyperglycemic, antioxidant and antihyperlipidemic properties of CHE could be helpful to maintain the activities of membrane-bound
ATPases in STZ-induced diabetic rats showing the membrane stabilizing property of extract.