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INFLUENCE OF CARDIOSPERMUM HALICACABUM LEAF EXTRACT ON MEMBRANE-BOUND ATPases IN STREPTOZOTOCIN-INDUCED DIABETIC RATS Veeramani, Chinnadurai; Al-Numair, Khalid S.; Chandramohan, Govindasamy; Alsaif, Mohammed A. & Pugalendi, Kodukkur Viswanathan Abstract Background: Cardospermum halicabum L. proved to have anti-inflammatory, antihyperglycemic, antioxidant, antiglycation, analgesic and antipyretic activities. It also has been used in Ayurveda and folk medicine for the treatment of rheumatism, fever and earache. Objective: The present study was aimed to evaluate the effect of Cardiospermum halicabum leaf extract (CHE) on membrane-bound ATPases in streptozotocin (STZ)-induced diabetic rats. Methods: Diabetes was induced in male albino Wistar rats by intraperitonial administration of STZ (40 mg/kg BW). CHE (200 mg/kg BW) or glibenclamide (600 μg/kg BW) was administered orally once daily for 45 days to normal and STZ-induced diabetic rats. Results: The activities of membrane-bound ATPases such as total ATPase, Na+/K+-ATPase, Mg2+-ATPase and Ca2+-ATPase were significantly decreased in erythrocytes and tissues of STZ-induced diabetic rats. Oral administration of CHE to diabetic rats significantly increased the activities of these enzymes towards near normalcy. Conclusions: Thus, the present study indicates that the beneficial role of membrane-bound ATPases in STZ-induced diabetic rats. The antihyperglycemic, antioxidant and antihyperlipidemic properties of CHE could be helpful to maintain the activities of membrane-bound ATPases in STZ-induced diabetic rats showing the membrane stabilizing property of extract. Keywords Streptozotocin; blood glucose; diabetes; membrane-bound ATPases; Cardiospermum halicacabum

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