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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 12, No. 3, 2015, pp. 68-74
Bioline Code: tc15050
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 12, No. 3, 2015, pp. 68-74

 en INFLUENCE OF CARDIOSPERMUM HALICACABUM check for this species in other resources LEAF EXTRACT ON MEMBRANE-BOUND ATPases IN STREPTOZOTOCIN-INDUCED DIABETIC RATS
Veeramani, Chinnadurai; Al-Numair, Khalid S.; Chandramohan, Govindasamy; Alsaif, Mohammed A. & Pugalendi, Kodukkur Viswanathan

Abstract

Background: Cardospermum halicabum check for this species in other resources L. proved to have anti-inflammatory, antihyperglycemic, antioxidant, antiglycation, analgesic and antipyretic activities. It also has been used in Ayurveda and folk medicine for the treatment of rheumatism, fever and earache.
Objective: The present study was aimed to evaluate the effect of Cardiospermum halicabum leaf extract (CHE) on membrane-bound ATPases in streptozotocin (STZ)-induced diabetic rats.
Methods: Diabetes was induced in male albino Wistar rats by intraperitonial administration of STZ (40 mg/kg BW). CHE (200 mg/kg BW) or glibenclamide (600 μg/kg BW) was administered orally once daily for 45 days to normal and STZ-induced diabetic rats.
Results: The activities of membrane-bound ATPases such as total ATPase, Na+/K+-ATPase, Mg2+-ATPase and Ca2+-ATPase were significantly decreased in erythrocytes and tissues of STZ-induced diabetic rats. Oral administration of CHE to diabetic rats significantly increased the activities of these enzymes towards near normalcy.
Conclusions: Thus, the present study indicates that the beneficial role of membrane-bound ATPases in STZ-induced diabetic rats. The antihyperglycemic, antioxidant and antihyperlipidemic properties of CHE could be helpful to maintain the activities of membrane-bound ATPases in STZ-induced diabetic rats showing the membrane stabilizing property of extract.

Keywords
Streptozotocin; blood glucose; diabetes; membrane-bound ATPases; Cardiospermum halicacabum

 
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