Numerous plants in traditional practices of medicine have been used to treat cognitive disorders, including neurodegenerative
diseases such as Alzheimer's disease (AD) and other memory related disorders.
Materials and Methods:
We present here the evaluation of acetylcholinesterase (AChE) inhibitory and antioxidant activities of the aqueous
methanol extracts of five traditional medicinal plants. Citrullus colocynthis
, Emex spinosa
, Rhazya stricta
, Scrophularia hypericifolia
extracts were tested for their acetylcholinesterase inhibitory effect ant their antioxidant effect at different concentrations.
Results: Citrullus colocynthis
and Emex spinosa
inhibited acetylthiocholinesterase at 400 μg/ ml by 83.54 and 81.92%. Emex spinosa
produced the maximum effect as DPPH radical scavenger (IC50
= 10.89 and 11.88μg/ ml, respectively).
showed the highest effect as superoxide radical scavenger (IC50
= 20.83 μg/ ml)also it produced the highest ability to
scavenge hydrogenperoxide radicals (IC50
= 8.66 μg/ ml) while Emex spinosa
and Caylusea hexagyna
showed least IC50
for ferrous ion chelation
≈15 μg/ ml) with powerful reduction capability.
The determined antioxidant properties magnified the total antioxidant effect determined by ABTS assay that completely inhibited
lipidperoxidation at 200 μg/ ml.