The study was designed to study the anti-thrombosis activity of Carthamustinctorius
L. (CTL) ethanol extraction rats.
Material and Methods:
Common carotid artery FeCl3
-induced thrombus and inferior vena cava thrombosis occlusion time, plasma
concentrations of thromboxane B2(TXB2) and 6-keto-prostaglandin F1α(6-keto-PGF1α) were measured in rats.
Venous occlusion time was prolonged in rats. Arterial and venous thrombus weights were dose-dependently reduced in CTL
groups.TXB2 decreased and 6-keto-PGF1α increased with CTL and aspirin, with an association between 6-keto-PGF1α/TXB2 and arterial or
venous thrombus weight for all products, and for occlusion time with CTL but not for aspirin.
The experimental effects of CTL on thrombosis in rats were confirmed. Again, further explorations of putative clinical effects appear