Background: Antrodia cinnamomea
(AC) mycelia have been traditionally used by majority of the indigenous populace in Taiwan for symptoms
including treating alcohol intoxication. Other beneficial effects have been studied at some point. The present study evaluated the
hepato-protection effects in Sprague-Dawley rats.
The model used carbon tetrachloride (CCl4
) to induce a chronic liver injury in male rats. Animals were treated with silymarin 200
mg/kg and AC mycelia at doses of 206, 619 and 1,032 mg/kg. The effects of AC on hepatic enzyme markers alanine and aspartate
aminotransferase (ALT and AST) and other biochemical parameters were measured in the CCl4
AC demonstrated a hepato-protective effect by decreasing ALT and AST levels and increasing albumin levels in CCl4
treated rats. The
effects of AC on the activity of antioxidant enzymes were evaluated. AC administration restored the activities of catalase (CAT), glutathione
peroxidase (GPx) and glutathione reductase (GrD). The degree of liver fibrosis was significantly reduced by AC administration in CCl4
These results suggest that AC could protect the hepatocytes from CCl4 -induced liver injury likely via an antioxidant mechanism.