African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
Vol. 12, No. 4, 2015, pp. 65-71
Bioline Code: tc15076
Full paper language: English
Document type: Research Article
Document available free of charge
African Journal of Traditional, Complementary and Alternative Medicines, Vol. 12, No. 4, 2015, pp. 65-71
© Copyright 2015 - African Journal of Traditional, Complementary and Alternative Medicines
EFFECTS OF DANCHI DECOCTION ON P450AROM, SURVIVIN OF EUTOPIC ENDOMETRIUM OF PATIENTS WITH ENDOMETRIOSIS AFTER CONSERVATIVE SURGERY|
Yang, YanHuan; Zhao, RuiHua; Hao, ZengPing; Li, Li; Xu, Cai & Cui, YangYang
Background: Endometriosis is a common gynecological disease, which can seriously affect the physical and mental health of patients. However,
there is not a satisfactory way to treat endometriosis with a low recurrence rate.
Materials and Methods: Including twenty patients with endometriosis given conservative surgery, a prospective clinical study was performed
with randomly grouping and positive control. The traditional Chinese medicine (TCM) and western medicine (WM) groups were given Danchi
decoction and GnRH-a or gestrinone respectively. Treatment was given in 1–5 days during the first menstruation. The eutopic endometriums
were collected before and 3 months after the treatment, respectively. Then immunohistochemistry was performed to obtain the expressions of
P450arom and survivin. In the normal control (NC) group no drugs were administered.
Results: Before the treatment, the expressions of P450arom and survivin in both TCM and WM groups were much higher than the NC group
(P<0.05) and no significant differences between the two groups (P>0.05). The expressions of the two groups were remarkably decreased after
the treatment (P<0.05) and they had no difference between the two groups (P>0.05).
Conclusion: Danchi decoction can control the recurrence of endometriosis by restraining abnormal secretion of aromatizing enzyme and
regulating cell apoptosis in eutopic endometrium. Excessive expressions of aromatizing enzyme and decreased apoptosis are a possible
mechanism of endometriosis recurrence.
Endometriosis; Recurrence; Danchi Decoction; Eutopic endometrium
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