search
for
 About Bioline  All Journals  Testimonials  Membership  News  Donations


African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 12, No. 4, 2015, pp. 79-83
Bioline Code: tc15078
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 12, No. 4, 2015, pp. 79-83

 en QUANTITATIVE ESTIMATION OF GINSENOSIDES IN DIFFERENT AGES OF PANAX VIETNAMENSIS check for this species in other resources AND THEIR ANTI-PROLIFERATION EFFECTS IN HELA CELLS
Vo, Hoang Tung; Ghimeray, Amal Kumar; Vu, Ngoc Thang & Jeong, Yeon-Ho

Abstract

Background: The objective of study was to investigate the major compounds of ginsenosides in Panax vietnamensis check for this species in other resources in its growing stages and their anti-proliferative activity in HeLa cells.
Materials and Methods: The roots with different ages were analyzed by HPLC/MS. Anti-proliferation activity of P. Vietnamensis ginseng in HeLa cells was investigated using MTT assay.
Results: Three main compounds of ginsenoside, Rb1, Rg1 and majonoside R2 were increased with the increasing of age. However, ginsenoside Rc, Re, Rd and Rg3 did not show any alteration with growing age. The major compound majonoside R2 was accumulated maximum in 5 years old ginseng. According to the data, the anti-proliferation activity was directly proportional to the growing ages of ginseng. The eleven years old ginseng showed maximum effect than the younger roots. This effect may be related to the concentration of ginsenosides or majonoside R2 content in P. Vietnamensis.
Conclusion: The concentration of ginsenoside content in the roots of P. Vietnamensis is directly related to the growing ages. Overall, due to the higher concentration of ginsenoside in mature ginseng root, Panax vietnamensis ginseng can be used as an effective anti-proliferative drug.

Keywords
Panax vietnamensis; anti-proliferation activity; HeLa cells; ginsenosides; ages

 
© Copyright 2015 - African Journal of Traditional, Complementary and Alternative Medicines
Alternative site location: http://journals.sfu.ca/africanem/index.php/ajtcam

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2017, Site last up-dated on 16-Oct-2017.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Internet Data Center of Rede Nacional de Ensino e Pesquisa, RNP, Brazil