African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
Vol. 12, No. 5, 2015, pp. 46-52
Bioline Code: tc15096
Full paper language: English
Document type: Research Article
Document available free of charge
African Journal of Traditional, Complementary and Alternative Medicines, Vol. 12, No. 5, 2015, pp. 46-52
© Copyright 2015 - African Journal of Traditional, Complementary and Alternative Medicines
VASOCONSTRICTIVE EFFECT OF XINMAILONG INJECTION IN RAT AORTA|
Yang, Cui; Zhang, Lifang; Dai, Rong; Ji, Siping; Li, Fang; Shao, Weizai; Que, Yuling; Hu, Ling & Lin, Qing
Background: Cockroach has been traditionally utilized in China for the therapy of cardiovascular disorders, such as heart failure. The present
study was aimed to assess the vasoconstrictive effect of Xinmailong Injection (XML), a bioactive composite from American cockroach.
Methodology: The isometric tensions of rat aortic rings were measured after acutely treated with XML. Meanwhile, the systemic blood
pressures (SBPs) were recorded and the levels of the endothelium-derived cytokines in blood samples were detected after rats were administered
with XML for 3 days. Protein expression for the L-type Ca2+ channels (Cav1.2) was also determined in rat thoracic aorta.
Results: XML induced vasoconstrictions in rat aortic rings with or without endothelium. In addition, the vasoconstrictions due to the
extracellular Ca2+ influx and the intracellular Ca2+ release were also elevated by XML. After treatment with XML for 3 days, the level of
prostacyclin (PGI2) was markedly increased whereas the levels of nitric oxide (NO) and endothelin-1 (ET-1) were not significantly changed in
rats. Furthermore, expression of the Cav1.2 protein was significantly enhanced in aorta but the SBPs of rats were not influenced.
Conclusion: XML plays an important role in regulating vascular tone. The increases of the extracellular Ca2+ influx and the intracellular Ca2+
release may contribute to the vasoconstriction induced by XML. Our findings pave the ways to the better understandings of the therapeutic
effects of XML on cardiovascular system.
Xinmailong Injection; American cockroach; Vasoconstriction
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