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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 12, No. 5, 2015, pp. 84-88
Bioline Code: tc15102
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 12, No. 5, 2015, pp. 84-88

 en LAMIUM ALBUM check for this species in other resources OR URTICA DIOICA check for this species in other resources ? WHICH IS MORE EFFECTIVE IN DECREASING SERUM GLUCOSE, LIPID AND HEPATIC ENZYMES IN STREPTOZOTOCIN INDUCED DIABETIC RATS: A COMPARATIVE STUDY
Mehran, Mohammad Mohseni; Norasfard, Mohammad R.; Abedinzade, Mahmood & Khanaki, Korosh

Abstract

Objectives: Diabetes mellitus, the most common endocrine disorder, is defined by hyperglycaemia. Urtica dioica check for this species in other resources or stinging nettle is known to have antidiabetic effects. Lamium album check for this species in other resources or non stinging nettle is shown to have some beneficial effects such as antioxidant, and cytoprotective properties. The purpose of this study was to compare the effects of hydroalchoholic extract of L. album and U. dioica on serum glucose, lipids and hepatic enzymes level in sterptozotocin induced diabetic rats.
Methods: Thirty-two male Wistar rats were randomly assigned into four groups; normal control, diabetic control, diabetic treated with U. dioica (100 mg/kg/daily), diabetic treated with L. album (100 mg/kg/daily) for 28 days. Serum glucose, cholesterol, triglyceride (TG), alanin trasaminase (ALT), alkaline phosphatase (ALP) and aspartate transaminase (AST) were measured.
Results: U. dioica and L. album extracts caused significant decrease (p<0.05) in serum glucose level in diabetic rats. Compared to diabetic control, both extracts significantly decreased serum cholesterol, ALT, AST and ALP (p<0.05). The level of serum TG in diabetic rats treated with U. dioica was significantly lower than that of animals treated with L. album (p<0.05).
Conclusion: it seems that administration of U. dioica and L. album extracts in diabetic rats may have similar lowering effects on the level of serum glucose, cholesterol and hepatic enzymes, albeit U. dioica might be more effective in improving serum TG as compared with L. album.

Keywords
Diabetes; Glucose; Lamium album; Lipids; Rats; Urtica dioica

 
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