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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 12, No. 6, 2015, pp. 113-121
Bioline Code: tc15118
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 12, No. 6, 2015, pp. 113-121

 en PHOLIDOTA CHINENSIS check for this species in other resources ALLEVIATES AZOXYMETHANE/DEXTRAN SULFATE SODIUM-INDUCED COLORECTAL CARCINOGENESIS THROUGH INHIBITION OF TLR4 AND COX-2
Liu, Li-Long; Xu, Kai; Kang, Lu-Mei; Jiang, Shu-Ping; Wang, Qing-Hua; Zhang, Lei; Wan, Shao-Gui & Chen, Hong-Ping

Abstract

Background: Inflammatory bowel disease (IBD) always progresses to colorectal cancer (CRC) which is the second most frequent cause of death by cancer. It is about 2% of population in the lifetime worldwide who at the risk for development of CRC. Oxaliplatin is an effective anticancer drug used for the treatment of advanced CRC; however, it always causes a robust painful neuropathy. Pholidota chinensis check for this species in other resources is a Chinese folk herbal medicine which was used for treatment of inflammation such as gastroenteritis, duodenal ulcer and bronchitis.
Materials and Methods: The azoxymethane (AOM) and dextran sulfate sodium (DSS) were used to induce the colon tumor of mice. The effect of Pholidota chinensis on colon tumorigenesis was evaluated. Immunohistochemistry and semi-quantitative RT-PCR were used to detect the expression of toll-like receptor 4 (TLR4) and cyclooxygenase-2 (COX-2) in colon.
Results: Pholidota chinensis can alleviate the colon tumorigenesis. The prevention effects of Pholidota chinensis are similar to oxaliplatin. Specifically, administration of Pholidota chinensis solution suppresses the expression of the proliferating cell nuclear antigen (PCNA), toll-like receptor 4 (TLR4) and cyclooxygenase-2 (COX-2).
Conclusion: Our findings suggested that Pholidota chinensis participate in the regulation of colon cancer development through inhibiting the expression of TLR4 and COX-2.

Keywords
Pholidota chinensis; colorectal cancer; Toll-like receptor 4; Cyclooxygenase-2

 
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