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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 12, No. 6, 2015, pp. 169-179
Bioline Code: tc15125
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 12, No. 6, 2015, pp. 169-179

 en ANTIOXIDANTAND ANTIBACTERIALACTIVITY OF TODDALIA ASIATICA check for this species in other resources (LINN) LAM ROOT EXTRACTS
Shi, Lei; Ji, Zhi-qiang; Li, Yue-mei; Li, Yuan-yuan & Guo, Chang-sheng

Abstract

Background: Toddalia asiatica check for this species in other resources (Linn) Lam is a woody vine that is used medicinally in China, India, and East Africa. The aim of the present study was to examine the antioxidant and antibacterial activity of the roots of Toddalia asiatica (Linn) Lam (TA).
Materials and Methods: The antioxidant capacity of TA roots was determined using 1,1 iphenyl-2-picrylhydrazyl (DPPH), 2,2´-azino-bis(3-ethylbenzo-thiazoline-6-sulfonicacid) (ABTS), and the ferric reducing antioxidant potential (FRAP) assay. The antimicrobial activity of TA against Staphylococcus aureus check for this species in other resources (SA), methicillin-resistant S. aureus (MRSA), and extended-spectrum β-lactamase positive S. aureus (ESBLs-SA) was screened.
Results: Methanol and ethyl acetate extracts of TA exhibited strong antioxidant activity. The methanol extract had the highest antioxidant activity (DPPH, IC50=41.45 μg/mL; ABTS, IC50=8.34 μg/mL; FRAP=1304.8 ± 60.38 μmol Trolox equivalent (TE)/g), which was close to that of the positive control, butylated hydroxytoluene (BHT). The petroleum ether extract of TA showed the highest antimicrobial activity (SA, minimum inhibitory concentration (MIC) = 250 μg/disc; MRSA, MIC=125 μg/disc) when compared with that of ethyl acetate extract (SA, MIC=250 μg/disc) and methanol extract.
Conclusions: Investigation of methanol, petroleum ether, and ethyl acetate extracts of TA root revealed robust antioxidant activity in methanol extracts and strong antimicrobial activity against SA and MRSA in petroleum ether extracts.

Keywords
Toddalia asiatica (Linn) Lam; antioxidant; antibacterial

 
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