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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 13, No. 1, 2016, pp. 99-104
Bioline Code: tc16014
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 13, No. 1, 2016, pp. 99-104

 en ANTIOXIDANTACTIVITY OF POLYPHENOLS FROM TOONA SINENSIS check for this species in other resources ROEM SEEDS AND THE INHIBITION OF ALDOSE REDUCTASE
Wang, XiaoHong & Li, WanZhong

Abstract

Background: The seeds of Toona sinensis check for this species in other resources (Juss.) M. Roem (T. sinensis) have long been used in Traditional Chinese Medicine for the treatment of diabetes mellitus (DM) and its complications. The aim of this study was to investigate the antioxidant activity of different polyphenols fractions from Toona sinensis Roem (T. sinensis) seeds (PTSS) and the inhibition of aldose reductase (AR).
Methods: Macroporous resin was used to purify PTSS, and the antioxidant activities were evaluated with total antioxidant capacity and free-radical scavenging. AR inhibitory activities were investigated by employing various established systems.
Results: The polyphenol eluted by 60% alcohol (PTSS3) exhibit the highest antioxidant activity and AR inhibition, with an r value of 0.9924 ± 0.0066 in correlation analysis. The inhibition mechanism of PTSS3 on AR is uncompetitive inhibition.
Conclusion: This research demonstrates that PTSS offers potential for intervening diabetes mellitus and its complications.

Keywords
Toona sinensis seeds; polyphenol; antioxidization; aldose reductase; diabetes mellitus

 
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Alternative site location: http://journals.sfu.ca/africanem/index.php/ajtcam

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