Background: Geranium carolinianum
L. (Geraniaceae) is widely used for a variety of diseases including herpetic keratitis, eczema,
rheumatalgia etc. However, there is lack of relevant scientific research.
Materials and Methods:
GCE (125, 250, 500mg/kg body weight) was evaluated for its pharmacological properties by using the acetic
acid-induced writhing test, the hot plate test and the fresh egg white-induced paw edema in rats. The dimethylbenzene-induced mouse
inflammation model and the lipopolysaccharide (LPS)-induced rat fever model were employed and the acute toxicity of GCE was also
The Geranium carolinianum
aqueous extract (GCE) significantly inhibited the writhing responses in mice, increased reaction time of
mice in the hot plate test, and suppressed the fresh egg white-induced paw edema in rats and the dimethylbenzene-induced ear edema in mice
whilst attenuating LPS-induced fever in rats in a dose dependent manner. Furthermore, no deaths were observed when mice were orally
administered GCE up to 14 g/kg body weight (approximately 553 times of clinical dose).
GCE possesses analgesic, anti-inflammatory and antipyretic activities and is non-toxic at the doses used. The results of this
study support the clinical use and effectiveness of Geranium carolinianum
as an analgesic, anti-inflammatory and antipyretic agent in folk