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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 13, No. 1, 2016, pp. 105-113
Bioline Code: tc16015
Full paper language: English
Document type: Short Communication
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 13, No. 1, 2016, pp. 105-113

 en ANALGESIC, ANTI-INFLAMMATORY AND ANTIPYRETIC ACTIVITIES OF THE AQUEOUS EXTRACT OF GERANIUM CAROLINIANUM check for this species in other resources L
Li, Yuan; Ye, Ying; Wang, Su-Juan; Xia, Wei; Rahman, Khalid; Yue, Wei & Zhang, Hong

Abstract

Background: Geranium carolinianum check for this species in other resources L. (Geraniaceae) is widely used for a variety of diseases including herpetic keratitis, eczema, rheumatalgia etc. However, there is lack of relevant scientific research.
Materials and Methods: GCE (125, 250, 500mg/kg body weight) was evaluated for its pharmacological properties by using the acetic acid-induced writhing test, the hot plate test and the fresh egg white-induced paw edema in rats. The dimethylbenzene-induced mouse inflammation model and the lipopolysaccharide (LPS)-induced rat fever model were employed and the acute toxicity of GCE was also assessed.
Results: The Geranium carolinianum aqueous extract (GCE) significantly inhibited the writhing responses in mice, increased reaction time of mice in the hot plate test, and suppressed the fresh egg white-induced paw edema in rats and the dimethylbenzene-induced ear edema in mice whilst attenuating LPS-induced fever in rats in a dose dependent manner. Furthermore, no deaths were observed when mice were orally administered GCE up to 14 g/kg body weight (approximately 553 times of clinical dose).
Conclusions: GCE possesses analgesic, anti-inflammatory and antipyretic activities and is non-toxic at the doses used. The results of this study support the clinical use and effectiveness of Geranium carolinianum as an analgesic, anti-inflammatory and antipyretic agent in folk medicine.

Keywords
Plant drug; Pain; Inflammation; Pyrexia; Toxicity; Animal

 
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