Backgroud: The aim of the present study was to evaluate
in vivo anti-tumor activity of
Balanites aegyptiaca
fruits extracts in addition
to its role in cell cycle and apoptosis.
Materials and Methods: Antitumor activities of ethylacetae extract (EAE), ethanol extract (EE) and chloroform extract (CE) were tested
against different cell line Hep-2, MCF-7, HL-60 and HCV29T. Calculation of the IC50 values for these extracts confirmed that the most
potent plant extract was EAE (40 ug/ml) followed by EE (55ug/ml), CE (61ug/ml).
Results: The ethanolic and chloroform extracts showed lower difference in their potency, while the EAE was found to be more active
indicating for nonpolar active principles responsible for the anti-proliferative activity. The ethanolic extract was three times higher active
than the chloroform extract. The results obtained showed that EAE exert a significant anti-proliferative, enhancement of apoptosis and
modulation of cell cycle phases compared with vincristine.
Conclusion: The presence of alkaloids, flavonoids and Phenolics increase its efficiency as anti-proliferative action. EAE has promising
anti-cancer activity with higher activity than EE or CE extracts
