African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
Vol. 13, No. 2, 2016, pp. 94-100
Bioline Code: tc16035
Full paper language: English
Document type: Research Article
Document available free of charge
African Journal of Traditional, Complementary and Alternative Medicines, Vol. 13, No. 2, 2016, pp. 94-100
© Copyright 2016 - African Journal of Traditional, Complementary and Alternative Medicines
EVALUATION OF HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECTS OF INTERNAL SEPTUM OF WALNUT FRUIT IN ALLOXAN-INDUCED DIABETIC RATS|
Ghiravani, Zahra; Hosseini, Mehran; Hassanzadeh Taheri, Mohamad Mehdi; Fard, Mohammad Hassanpour & Abedini, Mohammad Reza
Backgroud: Todays, the popularity of herbal medicine is increasing worldwide. Due to importance the evaluation of medicinal
herbs efficacy and safety, the present study was conducted to investigate the antidiabetic and hypolipidemic effects of internal
septum of walnut fruit (ISWF) ethanolic extract in diabetic rats.
Materials and Methods: Alloxan diabetic rats treated orally with ethanolic extract of ISWF (0-400mg/kg) for 28 days. To evaluate
its anti-diabetic activity, the animals fasting blood glucose were determined on the first, 14th and 29th days. Moreover, oral glucose
tolerance test (OGTT) was performed in diabetic rats at the last day of the study. After 24h of last administration, the blood samples
were collected, and the Plasma lipids and liver enzymes levels were measured in fasting overnight rats.
Results: The extract significantly decreased blood glucose (p<0.001) on 14th and 29th days. In addition, OGTT revealed that the
hypoglycemic effect of the extract appeared at 90 minutes. Alanine aminotransferase and aspartate aminotransferase levels
significantly decreased in diabetic rats treated with the both doses (p<0.05). Both doses of the extract were able to decrease
triglyceride significantly (p<0.05) in treated diabetic rats, while only the lower dose of the extract (200 mg/kg) attenuate the total
cholesterol and low density lipoprotein (p<0.001).
Conclusion: These finding support the notion that ISWF is able to reduce hyperglycemia and hyperlipidemia risk in diabetic rats.
Juglans regia; internal septum; walnut fruit; Antidiabetic; Lipid profile
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