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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 13, No. 2, 2016, pp. 143-150
Bioline Code: tc16040
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 13, No. 2, 2016, pp. 143-150

 en THE EFFICACY AND SAFETY OF URTICA DIOICA IN TREATING BENIGN PROSTATIC HYPERPLASIA: A SYSTEMATIC REVIEW AND META-ANALYSIS
Men, Changping; Wang, Meng; Aiyireti, Maimaiti & Cui, Yuanshan

Abstract

Backgroud: Urtica dioica check for this species in other resources is extract from the root of a stinging nettle.
Materials and Methods: We carried out a systematic review and meta-analysis to assess the efficacy and safety of Urtica dioica for treating Benign prostatic hyperplasia (BPH). A literature review was performed to identify all published randomized double-blind, controlled trials of Urtica dioica for the treatment of BPH. The search included the following databases: MEDLINE, EMBASE, and the Cochrane Controlled Trials Register. The reference lists of the retrieved studies were also investigated.
Results: Five publications involving a total of 1128 patients were used in the analysis. Primary efficacy end points: the international prostate symptom score (IPSS) (the standardized mean difference (SMD) =-10.47, 95% confidence interval (CI) =-18.12 to -2.82, p=0.007); the peak urinary flow rate (Qmax) (SMD=4.37, 95%CI=1.55 to 7.19, p=0.002) and prostate volume (SMD=-3.63, 95%CI=-4.67 to -2.57, p<0.00001) indicated that Urtica dioica was more effective than the placebo or controls. Safety assessments included prostatic specific antigen (PSA) (SMD=-0.08, 95%CI=-0.23 to 0.07, p=0.31) showed that PSA levels were unaffected in both groups.
Conclusion: This meta-analysis indicates that Urtica dioica to be an effective and safe treatment for LUTS associated with BPH.

Keywords
Urtica dioica; lower urinary tract symptoms; lower urinary tract symptoms; lower urinary tract symptoms; Randomized controlled trial

 
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