Backgroud: Urtica dioica
is extract from the root of a stinging nettle.
Materials and Methods:
We carried out a systematic review and meta-analysis to assess the efficacy and safety of Urtica dioica
treating Benign prostatic hyperplasia (BPH). A literature review was performed to identify all published randomized double-blind,
controlled trials of Urtica dioica
for the treatment of BPH. The search included the following databases: MEDLINE, EMBASE, and
the Cochrane Controlled Trials Register. The reference lists of the retrieved studies were also investigated.
Five publications involving a total of 1128 patients were used in the analysis. Primary efficacy end points: the international
prostate symptom score (IPSS) (the standardized mean difference (SMD) =-10.47, 95% confidence interval (CI) =-18.12 to -2.82,
p=0.007); the peak urinary flow rate (Qmax) (SMD=4.37, 95%CI=1.55 to 7.19, p=0.002) and prostate volume (SMD=-3.63,
95%CI=-4.67 to -2.57, p＜0.00001) indicated that Urtica dioica
was more effective than the placebo or controls. Safety assessments
included prostatic specific antigen (PSA) (SMD=-0.08, 95%CI=-0.23 to 0.07, p=0.31) showed that PSA levels were unaffected in
This meta-analysis indicates that Urtica dioica
to be an effective and safe treatment for LUTS associated with BPH.