African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
Vol. 13, No. 2, 2016, pp. 151-155
Bioline Code: tc16041
Full paper language: English
Document type: Research Article
Document available free of charge
African Journal of Traditional, Complementary and Alternative Medicines, Vol. 13, No. 2, 2016, pp. 151-155
© Copyright 2016 - African Journal of Traditional, Complementary and Alternative Medicines
SAFETY ASSESSMENT OF LINUM USITATISSIMUM (LINN.) INGESTION IN NEW ZEALAND RABBITS|
Beroual, Katiba; Agabou, Amir; Bachtarzi, Karina; Haouam, Saïd & Hamdi-Pacha, Youcef
Backgroud: The therapeutic safety of herbal medicine is a major concern for consumers and users. After studying the effects of linseed on hair
growth in rabbits, the turn is to evaluate its safety by the observation of some clinical, biological and anatomo-pathological aspects.
Materials and Methods: A study was conducted during a period of three months on two groups of rabbits (control and test). Test group daily
received feed supplemented with 3g of ground linseed while the control animals received the same feed without any additives. Weekly, rabbits
were weighed and monthly blood samples were taken. By the end of the trial, liver and kidneys biopsies were analyzed for histological and
Results: There was no significant improvement in weight gain in the test group rabbits, in which biochemical parameters had differentially
evolved with a decrease in their Glycemia and cholesterolemia. There were also no modifications in their serum hepatic and renal marker
enzymes and their liver and kidneys exhibited noticeably normal histology without any anatomically detectable anomalies.
Conclusion: These findings confirm that prolonged linseed ingestion in rabbits is safe.
Linium usitatissium; rabbit; ingestion; safety
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