The aim of the present study was to assess the effect of Hawthorn ( Crataegus oxyacantha
) and physical activity. We
studied its effect on penicillin induced epilepsy. in gerbils.
Materal and Methods:
Epilepsy was induced by administration of peniciline G (500 IU, ip). The gerbils were divided randomly in
four groups (6 animals per each group) and studied as described below: 1) Control group 2) Exercise group (30 min/each day for 8
weeks) (Eg) 3) Extract group, 50mg/kg/day/animal in 1 ml saline, 3 h prior to exercise (Exe) 4) Exercise+Extract + (Exe+Ex). The
severity of epilepsy was observed and recorded.
The means of latencies (Mean±SE) were 236±45, 369±36, 386±58 and 433±37 ms in groups of control, Exe, Ex, and
Exe+Ex respectively. The mean spike latency significantly (P=0,033 F=3,560) decreased in Exe, Ex and Exe+Ex when compared
control. Although spike frequency significantly (P<0.05) diminished in groups of Exe and Ex, no significant decrease was observed
in control and Exe+Ex. Similar trend was seen for amplitude values. Spike amplitude values were determined to be significantly
(P<0.05) lower than those of control and Exe+Ex.
Crataegus oxyacantha extract has shown positive affect to ameliorate on some seizure parameters in this study.
However, further more advanced physiologic and neurochemical studies are required to determine the mechanisms involved.