African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
Vol. 13, No. 2, 2016, pp. 229-236
Bioline Code: tc16050
Full paper language: English
Document type: Research Article
Document available free of charge
African Journal of Traditional, Complementary and Alternative Medicines, Vol. 13, No. 2, 2016, pp. 229-236
© Copyright 2016 - African Journal of Traditional, Complementary and Alternative Medicines
NEUROTHERAPEUTIC EFFECT OF MANGIFERIN AGAINST HYPOXIC–ISCHEMIC ENCEPHALOPATHY IN NEONATAL RATS|
Lv, Xiu-li; Wang, Yi; Hu, Bing; Kang, Le; Xin, Jun & Zhang, Guo-Ying
Backgroud: Hypoxic–ischemic encephalopathy (HIE) in perinatal condition is highly associated with mortality and several
neurological disabilities. The present experiment was blueprinted to ascertain the protective efficacy of mangiferin (MF) against
hypoxic–ischemic brain injury in neonatal rats.
Materials and Methods: Fourth six neonatal rats (pups) were randomly separated into four groups as a sham group that received only
water (control; n=12), pups exposed to Hypoxic–ischemic (HI) insult (HI group-II; n=11), pups receiving 20 (MF 20+HI-III; n=11) or 40
(MF 40+HI-IV; n=12) mg/kg b. wt of MF dissolved in water via i.p. for 7 consecutive days as pretreatment regimen before HI insult as
well as one-time post treatment after HI insult.
Results: MF pretreatment for seven days considerably attenuated the cerebral infarct size, edema level, lipid peroxidation (MDA),
inflammatory markers (TNF-α, IL-1β, IL-6, and NF-p65 subunit) as well as greatly ameliorated the antioxidant activities of catalase
(CAT), superoxide dismutase (SOD), and glutathione reductase (GSH) and thereby maintaining the redox balance. The number of viable
neuronal count (nissl bodies) was exponentially increased on administration with both the dosages of MF. Both the dosages showed
substantial protection against HIE, however, 40 mg of MF exhibit superior neuroprotection in equivalence with 20 mg of MF.
Conclusion: The results of the present study distinctly proving the beneficial effect of MF against HIE by concomitantly improving
neuronal count and antioxidant status. Hence, we recommend MF might be used for treating neonatal HIE with some standard drugs.
Hypoxic–ischemic encephalopathy; Mangiferin; Antioxidant; Inflammation; Neuroprotective
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