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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 13, No. 3, 2016, pp. 16-21
Bioline Code: tc16054
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 13, No. 3, 2016, pp. 16-21

 en ASSESSING EFFECTS OF EQUISETUM RAMOSISSIMUM check for this species in other resources EXTRACT ON HEMATOLOGICAL AND SERUM BIOCHEMICAL PARAMETERS IN PREGNANT SPRAGUE-DAWLEY RATS
Alebous, Hana Dawood; Hudeb, Arwa Ali; Sober, Suzanne Ali; Gray, Rosianna & Johnson, Margaret Dean

Abstract

Background: As a medicinal herb, Equisetum ramossisemum check for this species in other resources has been utilized for centuries as a diuretic and has been recommended for different disorders. The aim of this study was to investigate the maternal toxicity of aerial parts of Equisetum ramosissimum extract on pregnant Sprague-Dawley rats.
Methods: Females were mated and the coupling time was recorded at gestation day 0– E0. Four experimental groups I, II, III, and IV, received daily gavage doses of 0 mg, 500 mg, 250 mg, and 125 mg/kg, respectively, of Equisetum ramosissimum extract. Pregnant rats were observed for mortality and toxicological effects during daily treatment. On day E20, samples of blood were withdrawn from the retro-orbital sinus under light ether anaesthesia for haematological and clinical chemistry examinations.
Results: Data analyses detected significant differences in biochemical and haematological parameters between the control group and other groups receiving extract.
Conclusion: This study constitutes a first approach to defining adverse effects of using Equisetum ramosissimum as a medicinal plant during pregnancy. Daily gavage doses of Equisetum ramosissimum extract produced significant differences in biochemical and haematological parameters in pregnant Sprague-Dawley rats as compared to the control group.

Keywords
Equisetum ramosissimum extract; Pregnant Sprague-Dawley rats; Haematology; Serum

 
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