As a medicinal herb, Equisetum ramossisemum
has been utilized for centuries as a diuretic and has been
recommended for different disorders. The aim of this study was to investigate the maternal toxicity of aerial parts of Equisetum
extract on pregnant Sprague-Dawley rats.
Females were mated and the coupling time was recorded at gestation day 0– E0. Four experimental groups I, II, III, and
IV, received daily gavage doses of 0 mg, 500 mg, 250 mg, and 125 mg/kg, respectively, of Equisetum ramosissimum
Pregnant rats were observed for mortality and toxicological effects during daily treatment. On day E20, samples of blood were
withdrawn from the retro-orbital sinus under light ether anaesthesia for haematological and clinical chemistry examinations.
Data analyses detected significant differences in biochemical and haematological parameters between the control group and
other groups receiving extract.
This study constitutes a first approach to defining adverse effects of using Equisetum ramosissimum
as a medicinal
plant during pregnancy. Daily gavage doses of Equisetum ramosissimum
extract produced significant differences in biochemical and
haematological parameters in pregnant Sprague-Dawley rats as compared to the control group.