African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
Vol. 13, No. 3, 2016, pp. 60-65
Bioline Code: tc16060
Full paper language: English
Document type: Editorial
Document available free of charge
African Journal of Traditional, Complementary and Alternative Medicines, Vol. 13, No. 3, 2016, pp. 60-65
© Copyright 2016 - African Journal of Traditional, Complementary and Alternative Medicines
THE PREVENTIVE EFFECT AND ENHANCE IMMUNITY FUNCTION OF BU-ZHONG-YI-QIWAN ON S180 TUMOR MICE.|
Hu, Fang; Liu, Xiao-ya; Chen, Xin-yue; Li, Can; Zhu, Rui-juan; Han, Huan; Li, Ying-dong & Feng, Shi-lan
Background: To evaluate the preventive effect and enhance immunity functions of Bu-zhong-yi-qi wan in vivo.
Materials and Methods: S180 tumor mice model was established by subcutaneous injection a dose of 0.2 ml (1×107/ml) at the right
oxter. The inhibitory rates, spleen indexes and thymus indexes were calculated. Splenic lymphocyte proliferative activity assay and
phagocytosis activity of peritoneal macrophages were done. Interferon (IFN-γ), interleukin (IL-2) and tumor necrotic factor (TNF-α) in
serum were detected.
Results: In the S180 tumor-bearing mice, Bu-zhong-yi-qi wan with medium-dose (975 mg/kg, 100 mg/l) had potent preventive effect and
anti-tumor effect, macrophage phagocytosis and Con A-stimulated splenocyte proliferation were increased as compared with model
control treatment. Bu-zhong-yi-qi wan could take part in the immune response by promoting the proliferation and differentiation of Tcells,
increasing the activity of the macrophages, inducing the generation of cell factor IL-2, TNF-α, IFN-γ.
Conclusion: It proved that Bu-zhong-yi-qi wan of medium-dose had great preventive effect and could enhance immunity function.
Bu-zhong-yi-qi wan; S180 tumor-bearing mice; preventive; immunity
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