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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 13, No. 3, 2016, pp. 140-149
Bioline Code: tc16069
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 13, No. 3, 2016, pp. 140-149

 en EVALUATION OF THE ACUTE AND SUBCHRONIC TOXICITY OF ZIWAN BAIBU TANG
Xin, Rui-hua; Peng, Wen-jing; Liu, Xiao-lei; Luo, Yong-jiang; Wang, Gui-bo; Luo, Chao-ying; Xie, Jia-sheng; Li, Jin-yu; Liang, Ge & Zheng, Ji-fang

Abstract

Background: Ziwan Baibu Tang (ZBT) is used as a traditional Chinese prescription used in the clinic to cure a variety of respiratory diseases. The objective of this study was to evaluate the acute and subacute toxicity of ZBT.
Materials and Methods: Fifty Kunming mice were assigned to 5 groups, and ZBT was administered at different concentrations. Symptoms, mortality and behavioural changes were recorded. Eighty Wistar rats were randomly allocated to 4 treatment groups or a control group for 4 weeks of treatment (half male and half female); general observations and weekly body weight (BW) gain were recorded. At the end of the 4-week experiment, the rats were sacrificed, and blood was collected for haematological and serum biochemical analyses. Samples from the primary organs were fixed in 10% buffered formalin for histopathological studies.
Results: The calculated LD50 of acute oral toxicity was 319.16 g/kg BW. After the 4-week treatment, BW did not significantly differ in any of the dose groups, compared with the control group (P>0.05), and the rat blood red blood cell (RBC) and haemoglobin (HGB) levels in each dose group did not significantly differ (P>0.05). In addition, serum urea and creatine levels in each dose group did not significantly differ from those in the control group (P>0.05).
Conclusion: These results indicate that ZBT does not possess toxic potential and that both the acute and subchronic toxicity in animals are very low.

Keywords
Ziwan Baibu Tang; acute; subchronic; toxicity; herbal

 
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