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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 13, No. 4, 2016, pp. 1-7
Bioline Code: tc16080
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 13, No. 4, 2016, pp. 1-7

 en ANXIOLYTIC - LIKE PROPERTIES OF Hallea ciliata check for this species in other resources IN MICE
Stephanie, Njapdounke Kameni Jacqueline; Gisele, Nkantchoua Nkamguie; Clarisse, Moto Okomolo Fleur; Germain, Taiwe Sotoing; Neteydji, Sidiki; Simon, Pale; Rigobert, Ayissi Mbomo Espoir & Elisabeth, Ngo Bum

Abstract

Background: The aim of the present study was to evaluate the anxiolytic properties of the decoction of stem bark of Hallea ciliata check for this species in other resources in mice. The decoction of Hallea ciliata is used in traditional medicine in Cameroon to treat diseases like anxiety disorders, fever, infantile convulsions and malaria.
Materials and methods: Stress induced hyperthermia, elevated plus maze, open field and hole-board tests were used. Four different doses of the decoction were administered to mice and their effects were compared to the effects of diazepam and vehicle. Phytochemical characterization of the decoction revealed the presence of alkaloids, flavonoids, tannins and saponins.
Results: Administration of Hallea ciliata resulted in a significant decrease of stress induced hyperthermia in mice at the doses of 29.5, 59 and 118 mg/kg. In the elevated plus maze test, Hallea ciliata increased the number of entries and the percentages of entries and time into the open arms, and reduced the number of entries and the percentages of entries and time into the closed arms. In the hole-board test, Hallea ciliata increased the number of both head-dipping and crossing and decreased the latency to the first head-dips and rearing. The decoction of Hallea ciliata and diazepam increased locomotion in the open field test.
Conclusion: The number of rearing and the mass of fecal boli produced were decreased in mice treated with decoction and diazepam. In conclusion, the results indicated that decoction of Hallea ciliata has anxiolytic-like properties in mice and could potentially be used for anxiety treatment.

Keywords
anxiety; herbs; pharmacology; diazepam

 
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