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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 13, No. 4, 2016, pp. 162-165
Bioline Code: tc16100
Full paper language: English
Document type: Short Communication
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 13, No. 4, 2016, pp. 162-165

 en ANTIPROTOZOAL ACTIVITY OF EXTRACTS OF ELAEODENDRON TRICHOTOMUM check for this species in other resources (CELASTRACEAE)
Roca-Mézquita, Carolina; Graniel-Sabido, Manlio; Moo-Puc, Rosa E.; Leon-Déniz, Lorena V.; Gamboa-León, Rubí; Arjona-Ruiz, Carely; Tun-Garrido, Juan; Mirón-López, Gumersindo & Mena- Rejón, Gonzalo J.

Abstract

Background: Chagas disease, amebiasis, giardiasis and trichomoniasis represent a serious health problem in Latin America. The drugs employed to treat these illnesses produce important side effects and resistant strains have appeared. The present study was aimed to evaluate the antiprotozoal activity of leaves, stem bark and root bark of Elaeodendron trichotomum check for this species in other resources , a celastraceus, that is used in Mexico as an anti-infective in febrile-type diseases.
Materials and methods: Dichloromethane and methanol extracts of leaves, bark and roots of Elaeodendron trichotomum were tested against Entamoeba histolytica check for this species in other resources , Giardia lamblia check for this species in other resources , Trichomonas vaginalis , and Trypanosoma cruzi . A quantitative HPLC analysis of pristimerin and tingenone was performed.
Results: The dichloromethane extract of roots was active against E. histolytica, G. lamblia, T. vaginalis, and T. cruzi, at IC50’s of 0.80, 0.44, 0.46, and 2.68 μg/mL, respectively. The HPLC analysis revealed the presence of tingenone (3.84%) and pristimerin (0.14%).
Conclusions: The dichloromethane extract of the roots bark showed significant activity against all screened protozoa.

Keywords
Elaeodendron trichotomum; antiprotozoal activity; Celastraceae; tingenone; pristimerin; root bark

 
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