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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 13, No. 4, 2016, pp. 184-190
Bioline Code: tc16103
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 13, No. 4, 2016, pp. 184-190

 en INHIBITORY EFFECT OF LYCOPENE AGAINST THE GROWTH OF HUMAN GASTRIC CANCER CELLS
Zhou, ShenKang; Zhang, RuiLi; Bi, TieNan; Lu, Yong & Jiang, LiangXian

Abstract

Background: The aim of this study was to investigate the anti-proliferative effect of Lycopene on HGC-27 cells.
Materials and methods: HGC-27 cells were treated with varying concentration lycopene for 24, 48, 72 h. The cell growth inhibition was analyzed by MTT. Western blotting was used to indicate changes in the levels of LC3-I, LC3-II, ERK (extracellular signal‐regulated protein kinase) and phosphorylation-ERK (p-ERK).
Results: Lycopene displayed antiproliferative activity in HGC-27 cell lines. Western blotting showed that Lycopene significantly enhanced LC3-I, p-ERK proteins expression. In gastric cancer nude mice model, lycopene treatment significantly decreased tumour weight. These findings indicated that lycopene treatment induces the anti-proliferation of HGC-27 cells.
Conclusion: Lycopene treatment inhibited HGC-27 cells growth by activating ERK.

Keywords
gastric cancer; HGC-27; Apoptosis; p-ERK

 
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