Background: Kaempferol, a natural flavonoid, has been shown to induce cancer cell apoptosis and cell growth inhibition in several
tumors. Previously we have conducted a full investigation on the chemical constituents of
Gynura medica
, kaempferol and its
glycosides are the major constituents of
G. medica. Here we investigated the growth inhibition and apoptosis induction effect of
kaempferol extracted from
G. medica.
Materials and Methods: The inhibition effects of kaempferol were evaluated by MTS assay and soft agar colony formation assay.
Fluorescence staining and western blotting were be used to study the apoptosis. The structure was identified by
1H- NMR),
13C-NMR and ESI-MS analyses.
Results: Our results showed that kaempferol’s inhibition of MCF-7 breast cancer cell growth may through inducing apoptosis and
downregulation of Bcl2 expression.
Conclusion: Kaempferol is a promising cancer preventive and therapeutic agent for breast cancer.
