Natural products including Agrimonia eupatoria
are considered an incomparable source of molecular diversity that
has led to the medicines, especially for pain treatment. To investigate the antinociception of Agrimonia eupatoria
, we examined its
activity in a rat model of cisplatin neuropathy.
Materials and Methods:
Male Sprague-Dawley rats received intraperitoneal (i.p.) cisplatin twice a week at a dose of 2 mg/kg
(cumulative dose, 20 mg/kg) for 4 weeks. Before each injection, 2 ml of sterile saline solution was given subcutaneously to prevent
renal damage via hyperhydration. The mice were treated with gabapetin as a positive control drug with a 100mg/kg intraperitoneal
injection. A. eupatoria
extract of 200mg/kg was solved in saline and then treated by oral administration.
The mice treated with A. eupatoria
showed lower withdrawal duration in the pin-prick and plantar tests, and a higher
withdrawal threshold in the paw-withdrawal threshold test as compared to control animals in a cisplatin-induced neuropathic model.
In the case of cold-allodynia, A. eupatoria
treatment increased paw-withdrawal duration in a chemical test. A. eupatoria
more outstanding effect than gabapentin in all used tests for preventing cisplatin-induced nerve injury for 4 weeks.
Our results suggest that A. eupatoria
extract showed an antinociceptive effect in the pin-prick test, plantar test, and
paw-withdrawal threshold test using a cisplatin-induced neuropathic rat model.