Background: The current trend globally is the utilization of natural products as therapeutic agents given its minimum side effects.
The leaves of
Stevia
contain several active ingredient compounds such as rebaudioside.
Stevia extract have been used for many
purposes. Active oxygen radicals can induce base modifications, DNA breakage, and intracellular protein crosslink's. This study was
done to evaluate the potential of
stevia extract as antibacterial and antioxidants actions.
Materials and methods: Antibacterial activity of different extracts of
stevia was tested in vitro against different species of bacteria
and hepato-protective efficacy was testes in rats injected with CCl
4 as hepatotoxic.
Results: Acetone extract exhibited antibacterial activity against selected five bacteria species. The acetone extract suppressed the
elevation of serum ALT (p <0.05) and AST (p <0.001) activities induced by CCl
4. Animals given stevia extract showed prevention
against deleterious effects of CCl
4 by lowering lipid peroxidation and enhancement of antioxidant activities as SOD and CAT. The
protection trial is better than treatment trial. Total phenolic content of aqueous and acetone extracts were found 30 mg and 85 mg
gallic /gm extract respectively. While the total flavonoids were 40 mg and 80 mg quercetin/g respectively. The GC-MS analysis
showed that monoterpene and indole are the main components. Aqueous extract don’t show any antibacterial activity against the
tested strains. The antioxidant properties were attributable to its phenolic content to scavenge free radicals.
Conclusion: Acetone extract possess a potent antimicrobial and activity against deleterious effect of CCl
4-caused liver damage.