Traditional Chinese medicine
has been widely used to treat various inflammatory diseases.
Taraxasterol is one of the main active components isolated from Taraxacum officinale
. Recently, we have demonstrated that
taraxasterol has the in vitro
anti-inflammatory effects. This study aims to determine the in vivo
anti-inflammatory effects of
taraxasterol against animal models.
Materials and Methods:
Anti-inflammatory effects were assessed in four animal models by using dimethylbenzene-induced mouse
ear edema, carrageenan-induced rat paw edema, acetic acid-induced mouse vascular permeability and cotton pellet-induced rat
Our results demonstrated that taraxasterol dose-dependently attenuated dimethylbenzene-induced mouse ear edema and
carrageenan-induced rat paw edema, decreased acetic acid-induced mouse vascular permeability and inhibited cotton pellet-induced
rat granuloma formation.
Our finding indicates that taraxasterol has obvious in vivo
anti-inflammatory effects against animal models. It will
provide experimental evidences for the traditional use of Taraxacum officinale
and taraxasterol in inflammatory diseases.