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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 14, No. 2, 2017, pp. 9-15
Bioline Code: tc17037
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 14, No. 2, 2017, pp. 9-15

 en ANTIBACTERIAL AND ANTIOXIDANT POTENTIAL OF STEM BARK EXTRACT OF BOMBAX CEIBA check for this species in other resources COLLECTED LOCALLY FROM SOUTH PUNJAB AREA OF PAKISTAN
Masood-ur-Rehman; Akhtar, Naveed & Mustafa, Rehan

Abstract

Background: Ethnic medication systems have been used extensively by humans since their origin. Now a day, in the developing countries these systems are being used due to their effectiveness and affordability. Especially inhabitants of rural areas still rely on these systems as first line of treatment against diseased conditions. Till now, majority of medicines is derived from the natural origin particularly plants owing to their little side effects and cost effectiveness.
Materials and Methods: In the present work, we evaluated antibacterial and antioxidant activity of methanolic extract of Bombax ceiba stem bark. Total phenolic and flavonoid contents were also assessed in the extract. The antioxidant capacity was determined by DPPH, Nitric Oxide scavenging and reducing power activity. For antibacterial activity, Gram-negative ( Escherichia coli check for this species in other resources , Pseudomonas aeruginosa check for this species in other resources and Salmonella typhi check for this species in other resources ) and Gram-positive bacteria ( Bacillus subtilis check for this species in other resources , Staphylococcus aureus check for this species in other resources ) were used.
Results: Phenolic content was 133.21±1.56 µg GAE/mg of extract while Flavonoid content was 997.93±2.14 µg QE/mg. Plant extract demonstrated strong antiradical activity with EC50 18.78 ± 0.69 and 23.62 ± 1.99µg/ml for Nitric Oxide and DPPH assay respectively while EC50 in case of reducing power activity was 139.4 ± 0.98µg/ml. Plant extract displayed inhibitory effect against microbial growth with S. typhi as the most resistant strain and Staphylococcus aureus the most sensitive one.
Conclusion: This study revealed that Bombax ceiba of local origin has broad spectrum antibacterial activity and it can also provide defense against oxidative stress.

Keywords
antibacterial; antioxidant; DPPH; Nitric oxide; Bombax ceiba

 
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