African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
Vol. 14, No. 2, 2017, pp. 65-74
Bioline Code: tc17043
Full paper language: English
Document type: Research Article
Document available free of charge
African Journal of Traditional, Complementary and Alternative Medicines, Vol. 14, No. 2, 2017, pp. 65-74
© Copyright 2017 - African Journal of Traditional, Complementary and Alternative Medicines
CARDIOPROTECTIVE ROLES OF THE CHINESE MEDICINAL FORMULA BAO-XIN-TANG ON ACUTE MYOCARDIAL INFARCTION IN RATS|
Wang, Yang; Wang, Weihao; Peng, Weijun; Liu, Weiping; Cai, Weijun; Xia, Zian; Zhang, Honggeng & Xing, Zhihua
Background: Bao-Xin-Tang (BXT) is a traditional Chinese medicinal formula used for the treatment of coronary heart disease and
known to have favorable therapeutic benefits. The current study was designed to determine whether BXT has a cardioprotective role
for acute myocardial infarction. The underlying mechanisms were also explored.
Materials and Methods: The Sprague-Dawley rat model of acute myocardial infarction was established by occluding the left anterior
descending branch of the coronary artery. After a 3-h ischemic period, we determined the myocardial infarction size, inflammatory
components, and antioxidant activities.
Results: The data showed that BXT could reduce the infarction size and lower the levels of C-reactive protein, interleukin-6, and
myeloperoxidase, and increase the activities of superoxide dismutase and the anti-inflammatory cytokine, interleukin-10. These results
indicate that administration of BXT, following acute myocardial infarction, could reduce infarct size.
Conclusion: The effects of BXT may be related to its anti-inflammatory and anti-oxidative properties
Bao-Xin-Tang; cardioprotective; infarction size; anti-inflammatory; anti-oxidative
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