African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
Vol. 14, No. 2, 2017, pp. 103-124
Bioline Code: tc17047
Full paper language: English
Document type: Research Article
Document available free of charge
African Journal of Traditional, Complementary and Alternative Medicines, Vol. 14, No. 2, 2017, pp. 103-124
© Copyright 2017 - African Journal of Traditional, Complementary and Alternative Medicines
EFFECTS OF SALVIA MILTIORRHIZAE ON THE KIDNEY OF RATS WITH SEVERE ACUTE PANCREATITIS AND OBSTRUTIVE JAUNDICE|
Ren, Guibing; Zhang, Xiping; Ding, Xiaowen; Zou, Dehong; Yang, Hongjiang; Meng, Xiaoru; Mo, Wenju; He, Xiangming & Zhao, Shuai
Background: Severe acute pancreatitis (SAP) and obstructive jaundice (OJ) are frequent recurring diseases that bring
about huge threat to human health. Some reports have demonstrated that Salviae miltiorrhizae can protect multiple
organs of SAP and OJ model animals or patients, but their related mechanisms were not clear. In this study, we
observed the effects of Salvia miltiorrhizae injection on apoptosis and NF-κB expression in kidney and explored the
protective effect and mechanism of Salvia miltiorrhizae on the kidney of SAP or OJ rats. The results obtained will
provide a theoretical basis for clinical application of Salvia miltiorrhizae.
Material and Methods: A total of 288 rats were used for SAP - and OJ-associated experiments. The mortality rates of
rats, the contents of serum BUN and CREA, the expression levels of Bax, NF-κB proteins and the apoptosis index were
Results: The pathological changes in the kidney of SAP or OJ rats in treated group were mitigated to varying degrees.
At 6 and 12 hours after operation in SAP rats or on 21 and 28 days after operation in OJ rats, the contents of serum
CREA in treated group were significantly lower than those in model control group; At 3 and 6 hours after operation,
the staining intensity of Bax protein of kidney in treated group was significantly lower than that in model control group;
on 14 days after operation, the apoptosis index in the kidney of OJ rats in treated group was significantly lower than
that in model control group.
Conclusion: Salvia miltiorrhizae can exert protective effects on the kidney of SAP and OJ rats.
severe acute pancreatitis; obstructive jaundice; Salvia miltiorrhizae; traditional Chinese medicine; rats; kidney; apoptosis; Bax; NF-κ B
Alternative site location: http://journals.sfu.ca/africanem/index.php/ajtcam