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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 14, No. 5, 2017, pp. 49-55
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Bioline Code: tc17057
Full paper language: English
Document type: Research Article
Document available free of charge
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African Journal of Traditional, Complementary and Alternative Medicines, Vol. 14, No. 5, 2017, pp. 49-55
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CHEMICAL COMPOSITION AND PROPHYLACTIC EFFECTS OF SATURJA KHUZESTANICA ESSENTIAL OIL ON ACUTE TOXOPLASMOSIS IN MICE
Mahmoudvand, Hossein; Beyranvand, Maryam; Nayebzadeh, Hassan; Fallahi, Shirzad; Mirbadie, Seyyed Reza; Kheirandish, Farnaz & Kayedi, Mohammad Hassan
Abstract
Background: Toxoplasma gondii is a widespread zoonotic protozoan that infects approximately one third of the global
human population and all other warm-blooded animals. The present study aims to evaluate the prophylactic effects of
Satureja khuzestanica essential oil (SKEO) on infected mice with acute toxoplasmosis.
Materials and Methods: The components of the SKEO were identified by gas chromatography/mass spectroscopy
(GC/MS). To evaluate the prophylactic effects of SKEO, mice were divided into four groups. (i) non-treated group, (ii)
mice treated with olive oil once a day for two weeks, (iii) mice treated with SKEO at the dose of 0.2ml/kg once a day
for two weeks, (iv) and mice orally treated with SKEO at the dose of 0.3 ml/kg once a day for two weeks. After 24 h
(fifteenth day) mice in the groups of two-four were infected intraperitonealy with 10-4 tachyzoite of T. gondii, RH
strain. The mortality rate in all infected mice and the number of tachyzoites from infected mice were recorded.
Results: The main components of SKEO were carvacrol (78.8%), thymol (7.5%), and beta-Bisabolene (1.2%).
Findings of prophylactic effects revealed that mortality rate of infected mice was 8 days after oral administration of
SKEO at the concentration of 0.2 and 0.3ml/kg (P<0.05). In contrast, this value for control group was 5 days. In
addition, SKEO significantly reduced the mean number of tachyzoites compared with control group (P<0.05). No
significant difference (P>0.05) was observed in the clinical chemistry and hematological parameters following oral
administrations of SKEO at the doses of 0.2 and 0.3 ml/kg for 14 days.
Conclusion: The results showed the potential of SKEO as a natural source for the production of new prophylactic agent
for use in toxoplasmosis.
Keywords
GC/MS; Satureja khuzestanica; Toxoplasma gondii; In vivo; Mice
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