African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
Vol. 14, No. 4, 2017, pp. 247-252
Bioline Code: tc17133
Full paper language: English
Document type: Short Communication
Document available free of charge
African Journal of Traditional, Complementary and Alternative Medicines, Vol. 14, No. 4, 2017, pp. 247-252
© Copyright 2017 - African Journal of Traditional, Complementary and Alternative Medicines
A MOUSE MODEL OF MAMMARY HYPERPLASIA INDUCED BY ORAL HORMONE ADMINISTRATION|
Sun, Li; Guo, Dong-Hui; Liu, Fei; Liu, Qian; Jiang, Ning; Sun, Yun-Feng; Cai, Li-Ping & Zheng, Hong-Xin
Background: Mammary hyperplasia is one of the most common benign breast disorders. Although traditional
Chinese medicine has a vast experience in the treatment of mammary hyperplasia, it is not accepted widely due to its
Methods and Materials: To address the mechanism, we developed a mouse model of mammary hyperplasia. We gave
mice estradiol valerate tablets and progesterone capsules sequentially for one month by intragastric administration.
Results: Mice treated by this method had a series of pathological changes which are similar to those detected in women
with mammary hyperplasia, including ectopic level of estradiol and progesterone in serum, hyperplasia of mammary
glands and increased expression of ERα and PR.
Conclusion: This model will facilitate the mechanical study of traditional medicine on mammary hyperplasia.
mouse model; mammary hyperplasia; estradiol valerate; progesterone; intragastric administration
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