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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 14, No. 4, 2017, pp. 247-252
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Bioline Code: tc17133
Full paper language: English
Document type: Short Communication
Document available free of charge
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African Journal of Traditional, Complementary and Alternative Medicines, Vol. 14, No. 4, 2017, pp. 247-252
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A MOUSE MODEL OF MAMMARY HYPERPLASIA INDUCED BY ORAL HORMONE ADMINISTRATION
Sun, Li; Guo, Dong-Hui; Liu, Fei; Liu, Qian; Jiang, Ning; Sun, Yun-Feng; Cai, Li-Ping & Zheng, Hong-Xin
Abstract
Background: Mammary hyperplasia is one of the most common benign breast disorders. Although traditional
Chinese medicine has a vast experience in the treatment of mammary hyperplasia, it is not accepted widely due to its
unclear mechanism.
Methods and Materials: To address the mechanism, we developed a mouse model of mammary hyperplasia. We gave
mice estradiol valerate tablets and progesterone capsules sequentially for one month by intragastric administration.
Results: Mice treated by this method had a series of pathological changes which are similar to those detected in women
with mammary hyperplasia, including ectopic level of estradiol and progesterone in serum, hyperplasia of mammary
glands and increased expression of ERα and PR.
Conclusion: This model will facilitate the mechanical study of traditional medicine on mammary hyperplasia.
Keywords
mouse model; mammary hyperplasia; estradiol valerate; progesterone; intragastric administration
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