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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 14, No. 4, 2017, pp. 247-252
Bioline Code: tc17133
Full paper language: English
Document type: Short Communication
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 14, No. 4, 2017, pp. 247-252

 en A MOUSE MODEL OF MAMMARY HYPERPLASIA INDUCED BY ORAL HORMONE ADMINISTRATION
Sun, Li; Guo, Dong-Hui; Liu, Fei; Liu, Qian; Jiang, Ning; Sun, Yun-Feng; Cai, Li-Ping & Zheng, Hong-Xin

Abstract

Background: Mammary hyperplasia is one of the most common benign breast disorders. Although traditional Chinese medicine has a vast experience in the treatment of mammary hyperplasia, it is not accepted widely due to its unclear mechanism.
Methods and Materials: To address the mechanism, we developed a mouse model of mammary hyperplasia. We gave mice estradiol valerate tablets and progesterone capsules sequentially for one month by intragastric administration.
Results: Mice treated by this method had a series of pathological changes which are similar to those detected in women with mammary hyperplasia, including ectopic level of estradiol and progesterone in serum, hyperplasia of mammary glands and increased expression of ERα and PR.
Conclusion: This model will facilitate the mechanical study of traditional medicine on mammary hyperplasia.

Keywords
mouse model; mammary hyperplasia; estradiol valerate; progesterone; intragastric administration

 
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