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Tanzania Journal of Health Research
Health User's Trust Fund (HRUTF)
ISSN: 1821-6404
Vol. 11, No. 4, 2009, pp. 226-234
Bioline Code: th09038
Full paper language: English
Document type: Research Article
Document available free of charge

Tanzania Journal of Health Research, Vol. 11, No. 4, 2009, pp. 226-234

 en Antiplasmodial, anti-trypanosomal, anti-leishmanial and cytotoxicity activity of selected Tanzanian medicinal plants
Malebo, H.M.; Tanja, W.; Cal, M.; Swaleh, S.A.M.; Omolo, M.O.; Hassanali, A.; Séquin, U.; Hamburger, M.; Brun, R. & Ndiege, I.O.

Abstract

The antiplasmodial, anti-trypanosomal and anti-leishmanial activity of 25 plant extracts obtained from seven Tanzanian medicinal plants: Annickia (Enantia) kummeriae (Annonaceae), Artemisia annua check for this species in other resources (Asteraceae), Pseudospondias microcarpa check for this species in other resources (Anacardiaceae), Drypetes natalensis check for this species in other resources (Euphorbiaceae), Acridocarpus chloropterus check for this species in other resources (Malpighiaceae), Maytenus senegalensis check for this species in other resources (Celastraceae) and Neurautanenia mitis check for this species in other resources (Papilonaceae), were evaluated in vitro against Plasmodium falciparum check for this species in other resources K1, Trypanosoma brucei rhodesiense check for this species in other resources STIB 900 and axenic Leishmania donovani check for this species in other resources MHOM-ET-67/82. Out of the 25 extracts tested, 17 showed good antiplasmodial activity (IC50 0.04-5.0 μg/ml), 7 exhibited moderate anti-trypanosomal activity (IC50 2.3- 2.8 μg/ml), while 5 displayed mild anti-leishmanial activity (IC50 8.8-9.79 μg/ml). A. kummeriae, A. annua, P. microcarpa, D. natalensis, M. senegalensis and N. mitis extracts had good antiplasmodial activity (IC50 0.04-2.1 μg/ml) and selectivity indices (29.2-2,250 μg/ml). The high antiplasmodial, moderate anti-trypanosomal and mild anti-leishmanial activity make these plants good candidates for bioassay-guided isolation of anti-protozoal compounds which could serve as new lead structures for drug development.

Keywords
Malaria, trypanosomiasis, leishmaniasis, medicinal plants, Tanzania

 
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