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Anti-Angiogenesis and Anti-Tumor Effect of Shark Cartilage Extract WANG Feng, WANG Yitao, XIE Liping, ZHANG Rongqing Abstract The effect of shark cartilage extract (SCE), purified in this laboratory, on angiogenesis in chick chorioallantoic membrane (CAM), on the activity of collagenase IV and on human umbilical vein endothelial cell (ECV-304) proliferation and apoptosis was investigated in vitro. The results showed that SCE caused a decline in CAM blood vessels and significantly prevented collagenase-induced collagenolysis. Moreover, SCE produced a dose-dependent decline in ECV-304 proliferation and altered its normal cell cycle. These results suggest that the anti-angiogenesis and anti-tumor effects of shark cartilage may be due to inhibition of endothelial cells as well as collagenolysis. Keywords shark cartilage extract; angiogenesis; chorioallantoic membrane; collagenase; endothelial cell

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