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Effect of Surface Modification on Microbiol Polyhydroxyalkanoate Films on Biocompatibility YANG Xianshuang , ZHAO Kai, XIA Caihong, CHEN Jinchun, CHEN Guoqiang Abstract The purpose of this study was to investigate in vitro biocompatibility of a new type of polymer, polyhydroxybutyrate-co-hexanoate (PHBHH x). The hydrop hilicity and biocompatibility were studied with two kinds of enzymes, amylase BA N480L and lipase Novozym388. The degree of hydrophilicity was observed using con tact angle measurements. in vitro biocompatibility evaluations were carried out by direct incubation of mouse fibroblast cell line L929 on the polyhydroxyalkano ate (PHA) films. The sa mples treated with BAN480L showed that the PHA biocompatibility increased while the hydrophilicity decreased. Relative to untreated samples, the number of cells on the Novozym388 modified PHBHHx significant decrease as the hydrophilicity al so decreased. The results indicated that other surface characteristics besides h ydrophilicity influence the biocompatibility of PHBHHx films. Keywords polyhydroxybutyrate-co-hexanoate (PHBHHx); hydrophilicity; biocomp atibility

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