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Tsinghua Science and Technology
Tsinghua University, China
ISSN: 1007-0212
Vol. 6, No. 3, 2001, pp. 248-252
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Bioline Code: ts01075
Full paper language: English
Document type: Research Article
Document available free of charge
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Tsinghua Science and Technology, Vol. 6, No. 3, 2001, pp. 248-252
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Computational Biology Study of S100 Family with Suggestions for Crystallization
WANG Yu, YE Sheng, RUAN Ge, M. Bartlam, JIANG Fan, RAO Zihe
Abstract
The S100 family is a class of calcium-regulated proteins with EF-hand. They are widely distributed and are implicated in diverse intracellular and extracellular physiological processes. A study of the S100 family using computational biology methods such as multiple sequence alignment, structural alignment and the construction of an evolutionary tree will promote understanding of S100 protein structures and their function, and could provide suggestions for crystallization.
Keywords
S100 family; computational biology; sequence alignment; structural alignment; crystallization
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