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Tsinghua Science and Technology
Tsinghua University, China
ISSN: 1007-0212
Vol. 6, No. 5, 2001, pp. 401-405
Bioline Code: ts01087
Full paper language: English
Document type: Research Article
Document available free of charge

Tsinghua Science and Technology, Vol. 6, No. 5, 2001, pp. 401-405

 en Different Modes of the Effect of 1,2-Propanediol and Azone on Stratum Corneum Lipids
WANG Hongwu, LI Fei, GONG Yandao, DONG Min, ZHANG Xiufang, ZHAO Nanming

Abstract

The stratum corneum (SC) controls the diffusion and penetration of drugs into and through the skin. In this investigation, differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR) were used to study the effect of two enhancers, 1,2-propanediol and azone, on lipids extracted from SC (SC lipids). The two enhancers affected the SC lipids. However, their function modes were different. The penetration enhancing mechanisms of the two enhancers are discussed based on their effects on SC lipids and on their efficiencies in arbutin permeation enhancement

Keywords
stratum corneum (SC); permeation; 1,2-propanediol ; azone; Fourier transform infrared spectroscopy (FTIR); differential scanning calorimetry (DSC)

 
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