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VITAE Academia Biomédica Digital
Centro de Análisis de Imágenes Biomédicas Computarizadas-CAIBC0
ISSN: 1317-987x
No. 52, 2012, pp. 1-10
Bioline Code: va12033
Full paper language: English
Document type: Research Article
Document available free of charge

VITAE Academia Biomédica Digital, No. 52, 2012, pp. 1-10

 es Marcadores inflamatorios en escolares obesos
Angulo, Nerkis; Barbella de Szarvas, Sobeida; Guevara, Harold; Mathison, Yaira; González, Dora; Hadad, Erika & Hernández, Ana

Resumen

En niños obesos se han detectado concentraciones elevadas de algunas citoquinas, relacionadas con indicadores de aumento de la grasa corporal y riesgo cardiovascular. Se Determinó valores de marcadores inflamatorios (Proteina C Reactiva ultrasensible, Fibrinógeno y Factor de Necrosis Tumoral α), en escolares obesos y su relación con indicadores de alarma cardiovascular. Estudio descriptivo-correlacional en 160 escolares prepúberes (88 obesos y 72 eutróficos). Se evaluaron tiempo de evolución de la obesidad, presión arterial, valoración nutricional, bioquímica. Se encontraron, mayores promedios (p<0,05), de Proteina C Reactiva ultrasensible (PCRus) y Fibrinógeno en los obesos. No hubo diferencias significativas de los valores de Factor de Necrosis Tumoral alfa (TNF-α), entre ambos grupos. La PCRus evidenció, una correlación significativa (p<0,05), con el Índice de masa corporal, área grasa, circunferencia de cintura e insulina postprandial. El Fibrinógeno, presentó una correlación significativa (p<0,05), con el porcentaje de grasa corporal, colesterol total y lipoproteínas de baja densidad (LDL-c).

Palabras-clave
Obesidad infantil, marcadores inflamatorios, riesgo cardiovascular.

 
 en Inflammatory markers in obese schoolchildren
Angulo, Nerkis; Barbella de Szarvas, Sobeida; Guevara, Harold; Mathison, Yaira; González, Dora; Hadad, Erika & Hernández, Ana

Abstract

High concentrations of some cytokines, related to indicators of increased body fat and high cardiovascular risk factors have been detected in obese schoolchildren. We determined the values of inflammatory markers (Ultrasensitive C Reactive Protein, Fibrinogen, and Tumoral Necrosis Factor α) in obese schoolchildren and their relationship to cardiovascular alarm indicators. A descriptive-correlational study, of 160 pre-pubescent schoolchildren (88 obese and 72 eutrophic). Time of evolution of obesity, blood pressure, nutritional, biochemical status were assessed. Higher averages (p <0.05) of Ultrasensitive C Reactive Protein (U-CRP) and Fibrinogen were found in obese children. There were no significant differences in the values of Tumoral Necrosis Factor alfa (TNF-α), between the two groups. The U-CRP, showed a significant correlation (p < 0.05), with the rate of body mass, fat area, circumference of waist and postprandial insulin. The Fibrinogen, presented a significant correlation (p <0.05), with the percentage of body fat, total cholesterol and low-density (LDL-c) lipoproteins.

Keywords
childhood obesity, inflammatory markers, cardiovascular risk.

 
© Copyright 2012 - Facultad de Medicina - Universidad Central de Venezuela
Alternative site location: http://vitae.ucv.ve

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