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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 26, No. 3, 2005, pp. 225-229
Bioline Code: zr05001
Full paper language: Chinese
Document type: Research Article
Document available free of charge

Zoological Research, Vol. 26, No. 3, 2005, pp. 225-229

 en A New Method for Detecting Natural Selection at the Level of Nucleotide Sites
LI Xin, CHEN Hong, WANG Wen

Abstract

Although noncoding regions play an important role in gene expression and regulation,it is difficult to detect natural selection at this level. Recently,some studies use the ratio (ω) between the nucleotide substitution rate in the detected regions and the nucleotide substitution rate in neutral regions as an indicator to detect natural selection in noncoding regions. However,to the noncoding regions,it's more informative to identify those nucleotide sites under positive selection. We developed a new maximum likelihood method to detect natural selection at the nucleotide site level and to identify those nucleotide sites that may contribute to functional divergence. This method can be applied to both coding regions and noncoding regions. Appling this method to previous reported genes that subjected to positive selection shows that this method is efficient to detect natural selection on nucleotide sites both in coding regions and noncoding regions.

Keywords
Natural selection; Noncoding region; Maximum-likelihood method

 
© Copyright 2005 Kunming Institute of Zoology, the Chinese Academy of Sciences
Alternative site location: http://www.zoores.ac.cn/

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