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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 26, No. 3, 2005, pp. 328-331
Bioline Code: zr05017
Full paper language: Chinese
Document type: Research Article
Document available free of charge

Zoological Research, Vol. 26, No. 3, 2005, pp. 328-331

 en A Thrombin Inhibitor from Ixodid Tick, Ixodide sinesis check for this species in other resources
WANG Li-ju, GAO Guo-fu, BAI Shi-ping, LIU Zhi-gang, LIANG Jian-guo, et al.


A novel thrombin inhibitor was identified and purified from salivary glands of ixodid tick, Ixodide sinesis check for this species in other resources by gel filtration and RP-HPLC. The molecular weight was 6.356 kDa determined by MALDI-TOF mass spectra. It was different from any known serine protease inhibitors identified from ixodid ticks. This inhibitor inhibited thrombin with strong potency,and exhibited no obvious effects on factor Xa and trypsin. The thrombin inhibitor may be used as a candidate to develop vaccine to control ticks.

Ixodide sinesis; Thrombin inhibitor; Serine protease; Salivary gland

© Copyright 2005 Kunming Institute of Zoology, the Chinese Academy of Sciences
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