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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 27, No. 5, 2006, pp. 541-548
Bioline Code: zr06077
Full paper language: Chinese
Document type: Research Article
Document available free of charge

Zoological Research, Vol. 27, No. 5, 2006, pp. 541-548

 en Progress in Anti-HIV-1 Actions of Ribosome Inactivating Proteins
WANG Jian-hua, OUYANG Dong-yun, WANG Yuan-yuan, ZHENG Yong-tang

Abstract

The anti-HIV-1 research history of ribosome inactivating proteins (RIPs) can be traced back to McGrath's work in 1989. They are important representatives, which guide further research, of natural anti-HIV products or leading compounds. The enzymatic activities and anti-HIV-1 actions of RIPs were introduced initially in this paper, followed by a detailed discussion about the potential anti-HIV-1 mechanisms. The discussion mainly focuses on the relationships with anti-HIV-1 enzymatic activities, induction of apoptosis of HIV-1 infected cells and responding cell signaling, the production of reactive oxygen species, the HIV-1 integrase inhibition effect. The anti-HIV-1 structure-functional relationship of RIPs and the structural modifications were also covered. Systemic and intensive studies of RIPs' antiviral actions will increase their possibility as clinical anti-HIV/AIDS agents.

Keywords
Ribosome inactivating protein; Trichosanthin; RNA-N Glycosidase; Antiviral mechanism; HIV-1

 
© Copyright 2006 Kunming Institute of Zoology, the Chinese Academy of Sciences
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