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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 28, No. 5, 2007, pp. 485-490
Bioline Code: zr07074
Full paper language: Chinese
Document type: Research Article
Document available free of charge

Zoological Research, Vol. 28, No. 5, 2007, pp. 485-490

 en New Proof for Astrocytes Having L-type Calcium Channels
WANG, Lei & CAI, Jing-xia

Abstract

The laser scanning confocal microscope and fluorescence spectrophotometer were used to investigate the effects of the L-type calcium channel agonist 1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl] pyridine-3- carboxylic acid [(±)-Bay k8644] and antagonist nimodipine on intra-cellular calcium concentration ([Ca2+]i ) of cultured mouse astrocyetes. The results showed that Bay K8644 can significantly increase the [Ca2+]i in cultured astrocytes at doses of 0.0001, 0.001 and 0.01 mmol/L, whereas nimodipine can decrease the [Ca2+]i at doses of 0.001, 0.01 and 0.1 mmol/L. Nimodipine can also decrease the elevation of [Ca2+]i elicited by KCl. Our results suggest that the effects of L-type calcium channel agonist and antagonist on astrocyes are the same as those on neurons, it indicates that astrocytes also have L-type calcium channels.

Keywords
Astrocyte; Intra-cellular calcium concentration([Ca2+]i); Nimodipine; Bay k8644; L-type calcium channel

 
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Alternative site location: http://www.zoores.ac.cn/

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