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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 28, No. 5, 2007, pp. 556-562
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Bioline Code: zr07085
Full paper language: Chinese
Document type: Research Article
Document available free of charge
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Zoological Research, Vol. 28, No. 5, 2007, pp. 556-562
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Application of AIDS Macaque Animal Model in HIV Vaccine Research
ZHANG, Gao-hong; LI, Ming-hua & ZHENG, Yong-tang
Abstract
HIV vaccine has become one of the research hotspot for the researchers in the world. Animal model is an
important tool for AIDS vaccine research. The slow progress in AIDS vaccine partially imputes to be lack of appropriate
animal models. SIV/SHIV macaque model has been widely used in AIDS research. However, there are some limitations
inherent in the current models that use either macaque animals or viruses. In order to exploit the potential of nonhuman
primate models in AIDS vaccine development, finding a better standardization animal model is an urgent necessity in
HIV research. In this review, the strategy and progress towards development of a HIV vaccine, and the present research
status and applied prospects of SIV/SHIV macaque model in HIV vaccine research were summarized.
Keywords
AIDS; SIV; SHIV; Vaccine; Macaque; Animal model
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© Copyright 2007 Kunming Institute of Zoology, the Chinese Academy of Sciences Alternative site location: http://www.zoores.ac.cn/
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