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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 29, No. 1, 2008, pp. 49-55
Bioline Code: zr08008
Full paper language: Chinese
Document type: Research Article
Document available free of charge

Zoological Research, Vol. 29, No. 1, 2008, pp. 49-55

 en Assessing Exploratory Behavior and Memory in ICR, BALB/c and C57BL/6 Mice Using Habituation
SHI, Jun-wei; ZOU, Hong & JIN, Mei-lei


Differences in exploratory, rearing and locomotion activity of ICR, BALB/c and C57BL/6 strain were investigated by a 16-hole board task and an open field with an automated infrared detecting system. ICR mice had the highest response rate while C57BL/6 mice had the lowest. It took less time for ICR mice to get used to a new environment and its performance in memory testing was also superior to C57BL/6 mice. The results confirmed the feasibility of using a hole-board test to assess memory. Comparisons between the trend of rearing and hole-poking activity demonstrated that the rearing behavior of mice, to a certain degree, reflected its exploratory and cognitive ability. Our results provided firm support for the notion that selection of a mouse strain is essential when conducting studies on higher cognitive behavior in mice.

Animal behavior; Strain; Exploratory behavior; Habituation; Memory

© Copyright 2008 Kunming Institute of Zoology, the Chinese Academy of Sciences
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