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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 29, No. 1, 2008, pp. 56-62
Bioline Code: zr08009
Full paper language: Chinese
Document type: Research Article
Document available free of charge

Zoological Research, Vol. 29, No. 1, 2008, pp. 56-62

 en Age-Related Changes in Neurons and S100-, GFAP-Immunoreactive Cells in the Motor Cortex of Cats
SHEN, Lin; SUN, Qing-yan; KAO, Chuan-chao & HUA, Tian-miao


Morphological changes of neurons and S100-,GFAP-immunoreactive cells in the motor cortex of young adult and older cats were comparatively investigated, and the correlation of these changes and motor function degradation during senescence was discussed. Nissl staining was applied to show cortical layers and neurons. Immunohistochemical method was employed to exhibit S100-immunoreactive (S100-IR) and GFAP-immunoreactive (GFAP-IR) cells. Under an Olympus microscope, Moitcam 5000 Digital Image Acquisition and Analysis System was used to statistically count the number of total cortical neurons, GFAP-IR cells and S100-IR cells in each cortical layer, and the cell-body diameter of GFAP-IR cells and S100-IR cells were randomly sampled and measured. The density of total neurons in layer V and VI of the motor cortex showed a significant decrease in older cats (P < 0.01). Furthermore, the density and the cell-body diameter of GFAP-IR and S100-IR cells in the motor cortex of old cats were significantly increased when compared to that in young adults (P < 0.01). In addition, the S100 and GFAP immunoreactivity in the motor cortex of older cats was stronger than in younger ones. The density of total neurons in layer V and VI of the motor cortex was significantly reduced during aging, which might lead to a decreased motion mediation capacity of the motor cortex in older individuals. Moreover, with age, astrocytes in the motor cortex were significantly activated and increased, which is of great significance in maintaining normal neuronal activities, signalling between neurons and therefore slowing down age-dependent motor function degradation

Motor cortex;Astrocyte;S100 protein;Glial fibrillary acidic protein;Age-related change

© Copyright 2008 Kunming Institute of Zoology, the Chinese Academy of Sciences
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