Effects of Vitamin E on Reproduction Endocrine and Ovary Structures in Mice Acutely Treated with TCDD

The study was conducted to investigate the effects of vitamin E (VE) on reproduction endocrine and ovary structures in mice acutely treated with TCDD. Twenty-four mice were divided into control groups, TCDD-treated with 30 ug/kg group, and a TCDD-treated with 30 μg/kg followed with 100 mg/kg vitamin E group. The level of progesterone and estradiol of plasma were analyzed by radio-immunity methods. The number of ova and the ovary forms were counted and observed under the microscope. The results showed that TCDD obviously decreased the level of plasma progesterone and the number of ova, changed the forms of ovaries, while 100 mg/kg VE significantly alleviated these effects caused by TCDD. TCDD and VE had no significant effects on the levels of plasma estradiol. The results indicated that VE had anti-actions on the endocritic function and a decrease in the progesterone level and the ova number in mice, caused by TCDD.