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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 29, No. 4, 2008, pp. 427-430
Bioline Code: zr08065
Full paper language: Chinese
Document type: Research Article
Document available free of charge

Zoological Research, Vol. 29, No. 4, 2008, pp. 427-430

 en Inhibitory Effect of Fluorocitrate on the Proliferation of Cultured Glioblastomas G422 Cells
QU, Jia-gui; WANG, Zheng-bo; DONG, Jin-run & MA, Yuan-ye

Abstract

In the present study, the effects of fluorocitrate on the proliferation of cultured glioblastomas G422 cells were investigated. Proliferation of glioblastomas G422 cells was measured by MTT assay at 36 h, 48 h and 60 h after fluorocitrate (0.0025 mmol/L, 0.005 mmol/L, 0.01 mmol/L, 0.025 mmol/L and 0.1 mmol/L) treatment. Our results showed that: (1) Fluorocitrate inhibited the proliferation of glioblastomas G422 cells in a dose dependent manner; (2) The inhibition rate increased with treatment time at high concentrations of fluorocitrate (0.01 mmol/L, 0.025 mmol/L and 0.1 mmol/L); (3) The inhibition rate did not increase with treatment time at low concentrations of fluorocitrate (0.0025 mmol/L and 0.005 mmol/L). This study indicated that fluorocitrate inhibited the proliferation of glioma cells as a function of fluorocitrate concentration and treatment time.

Keywords
Fluorocitrate; Glioma cells; MTT; Proliferation; Inhibitory effect

 
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