About Bioline  All Journals  Testimonials  Membership  News

Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 29, No. 4, 2008, pp. 459-464
Bioline Code: zr08071
Full paper language: Chinese
Document type: Research Article
Document available free of charge

Zoological Research, Vol. 29, No. 4, 2008, pp. 459-464

 en Evolution of Metabolic Pathways
SUN, Gui-ling; JIANG, Yong-hai & WEN, Jian-fan


The metabolism of organisms is carried out through a series of metabolic pathways. How these ingeniously regulated and collaborated metabolic pathways evolved has been a fascinating and important question for some time. Since the ‘retro-evolution hypothesis’ was first put forward in 1945, there have been seven main hypotheses concerning the evolution of metabolic pathways, including ‘retro-evolution of pathways, ‘semi-enzymatic theory’, ‘forward development model’, ‘enzyme recruitment hypothesis’, ‘specialization of multifunctional enzyme’, ‘pathway duplication’, and ‘de novo invention of pathways’. Among them, the most popular hypotheses are ‘retro-evolution’ and ‘enzyme recruitment’, and recently greater attention has been paid to the ‘specialization of multifunctional enzyme’ hypothesis, due to its strong theoretical basis and experimental evidence. Here, all of the seven hypotheses were reviewed, and the development prospect of this field analyzed.

Metabolic pathway; Evolution; Hypothesis

© Copyright 2008 Kunming Institute of Zoology, the Chinese Academy of Sciences
Alternative site location:

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2023, Site last up-dated on 01-Sep-2022.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Google Cloud Platform, GCP, Brazil